Tus thawj theem: Ua ntej 1900, nws yog tus rudiment ntawm niaj hnub fermenter, nrog yooj yim kub thiab kub pauv seev.
Nyob rau hauv lub thib ob theem: nyob rau hauv 1900-1940, ib tug 200m3 steel fermentation tank twb qhia thiab cov huab cua distributor twb pib nyob rau hauv ib tug neeg ua mov ci 's poov xab fermentation tank thiab tus neeg kho tshuab ntxhov siab twb siv nyob rau hauv ib tug me me fermentation tank.
Qhov thib peb theem ntawm npias fermentation khoom: 1940-1960, neeg kho tshuab stirring, cua, aseptic lag luam thiab purebred kab lis kev cai, ib tug series ntawm cov hom kev kawm pib los txhim kho, cov fermentation txheej txheem parameter nrhiav kom tau thiab tswj tau tshwm sim, cov kuj mus zog kom tsis muaj menyuam on-line mus kev txiav txim ntawm ph electrode thiab yaj oxygen electrode, lub computer pib los tswj lub fermentation txheej txheem. Qhov kev sib cais thiab purification khoom ntawm fermented khoom maj realizes commercialization.
Theem IV: 1960-1979, lub volume ntawm cov neeg kho tshuab zaj thiab ventilating fermentation tank ntau zog rau 80-150m3. Vim hais tias ntawm qhov yuav tsum tau rau cov loj-scale zus tau tej cov ib leeg-cell cov nqaijrog, muaj yog ib tug siab voj voog thiab ib tug siab dav hlau-hom fermentation tank, uas muaj peev xwm kov yeej-ib co nkev pauv thiab tshav kub pauv teeb meem. Lub computer pib tau lug siv nyob rau hauv lub fermentation kev lag luam.
Theem Fifth: 1979 los qhia. Lub ceev ceev txoj kev loj hlob ntawm bioengineering thiab technology tau muab tso rau pem hauv ntej ib tug tshiab lub npe rau cov fermentation kev lag luam. Raws li ib tug tshwm sim, loj-scale cell kab lis kev cai fermentation lauj kaub sawv, insulin, interferon thiab lwm yam txhob kaw engineered khoom rau lub commercialization.
